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Article

Single-point plasma or urine dextromethorphan method for determining CYP3A activity.

Biopharmaceutics & drug disposition - 1 Dec 2003

Kuo Benjamin Pei-Chung, Hu Oliver Yoa-Pu, Hsiong Cheng-Huei, Pao Li-Heng, Chen Ting-Shien, Hung Chi-Feng

Abstract excerpt

Dextromethorphan is used widely in vivo to phenotype the polymorphically expressed cytochrome P450 (CYP) 2D6. Also dextromethorphan is N-demethylated in vivo to 3-methoxymorphinan by human CYP3A4/5. The metabolic ratio (MR) of dextromethorphan/3-methoxymorphinan in plasma, saliva and urinary were examined as a possible in vivo probe of CYP3A activity. In limited previous studies, 4 h urinary samples were...

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PMID: 14689465
DOI: 10.1002/bdd.373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-point plasma or urine dextromethorphan method for determining CYP3A activity.PMID 14689465Read ↗

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