Heterogeneity of p53 mutational status in esophageal squamous cell carcinoma.

doi:10.1111/j.1349-7006.1998.tb00578.x

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Article

Heterogeneity of p53 mutational status in esophageal squamous cell carcinoma.

Japanese journal of cancer research : Gann - 1 Apr 1998

Kuwabara S, Ajioka Y, Watanabe H, Hitomi J, Nishikura K, Hatakeyama K

Abstract excerpt

In esophageal squamous cell carcinoma, p53 gene mutations have been analyzed for inter- or intra-patient heterogeneity but only a few studies have investigated intratumoral heterogeneity. We investigated this question within individual esophageal cancers, and also in their lymph-node metastases i...

Topics

Aged
Base Sequence
Carcinoma, Squamous Cell
Esophageal Neoplasms
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA
Tumor Suppressor Protein p53

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