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Article

Heterogeneity of p53 mutational status in esophageal squamous cell carcinoma.

Japanese journal of cancer research : Gann - 1 Apr 1998

Kuwabara S, Ajioka Y, Watanabe H, Hitomi J, Nishikura K, Hatakeyama K

Abstract excerpt

In esophageal squamous cell carcinoma, p53 gene mutations have been analyzed for inter- or intra-patient heterogeneity but only a few studies have investigated intratumoral heterogeneity. We investigated this question within individual esophageal cancers, and also in their lymph-node metastases in 8 cases. Analyzing the p53 gene sequence by direct sequencing of polymerase chain reaction products, we found...

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Identifiers

PMID: 9617346
DOI: 10.1111/j.1349-7006.1998.tb00578.x
PMCID: PMC5921814

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Source receipt: pubmed, retrieved 7 Sept 2026.

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