Article
[Multiregion sequencing reveals intratumor heterogeneity in esophageal squamous cell carcinoma].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 23 Sept 2016
Cao W, Wu W, Yan M, Tian F, Liu H S, Wang J W, Zhang Q W, Li Y J, Li M
Abstract excerpt
OBJECTIVE: To study the intratumor heterogeneity of esophageal squamous cell carcinoma (ESCC). METHODS: We used whole-exome sequencing and array-based comparative genomic hybridization to profile mutations and changes in copy number from 11 regions within 2 cases of ESCC and from the metastatic lymph nodes. RESULTS: The numbers of somatic single nuclear polymorphisms (SNPs) in 4 regions within the tumors in case...
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