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Article

Multiregion sequencing and subclonal analysis reveal intratumoral heterogeneity in esophageal squamous cell carcinoma.

Journal of cancer research and therapeutics - 1 Jul 2021

Gao Dongni, Zhang Zicheng, Yang Qiwei, Li Baosheng

Abstract excerpt

PURPOSE: The aim of this study was to investigate intratumoral genomic heterogeneity and subclonal structure of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: Multiregion whole-exome sequencing was performed on 24 surgically acquired tumor samples from five untreated ESCC patients collected in 2019 to determine the heterogeneity of mutational landscape within tumors. Phylogenetic analysis and...

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Identifiers

PMID: 34269310
DOI: 10.4103/jcrt.jcrt_270_21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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