Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers.

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Article

Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers.

Cancer research - 1 Jul 1995

Nagel S, Borisch B, Thein S L, Oestreicher M, Nöthiger F, Birrer S, Tobler A, Fey M F

Abstract excerpt

We investigated clonal intratumor heterogeneity by comparing different areas of each tumor in 20 gastrointestinal cancers from female patients (1 esophageal cancer, 5 stomach cancers, and 14 colorectal cancers). In all 19 cases informative for X-inactivation analysis with the M27 beta and/or the...

Topics

Alleles
Carcinoma
Clone Cells
DNA, Neoplasm
Dosage Compensation, Genetic
Female
Gastrointestinal Neoplasms
Genetic Markers
Heterozygote
Humans
Mutation
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 7796414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7796414-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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