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Article

The danger of metabolic pathways with turbo design.

Trends in biochemical sciences - 1 May 1998

Teusink B, Walsh M C, van Dam K, Westerhoff H V

Abstract excerpt

Many catabolic pathways begin with an ATP-requiring activation step, after which further metabolism yields a surplus of ATP. Such a 'turbo' principle is useful but also contains an inherent risk. This is illustrated by a detailed kinetic analysis of a paradoxical Saccharomyces cerevisiae mutant; the mutant fails to grow on glucose because of overactive initial enzymes of glycolysis, but is defective only in an...

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PMID: 9612078
DOI: 10.1016/s0968-0004(98)01205-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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