Article
Pathway swapping: Toward modular engineering of essential cellular processes.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Kuijpers Niels G A, Solis-Escalante Daniel, Luttik Marijke A H, Bisschops Markus M M, Boonekamp Francine J, van den Broek Marcel, Pronk Jack T, Daran Jean-Marc, Daran-Lapujade Pascale
Abstract excerpt
Recent developments in synthetic biology enable one-step implementation of entire metabolic pathways in industrial microorganisms. A similarly radical remodelling of central metabolism could greatly accelerate fundamental and applied research, but is impeded by the mosaic organization of microbial genomes. To eliminate this limitation, we propose and explore the concept of "pathway swapping," using yeast...
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