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Article

Optimal fluxes, reaction replaceability, and response to enzymopathies in the human red blood cell.

Journal of biomedicine & biotechnology - 1 Jan 2010

De Martino A, Granata D, Marinari E, Martelli C, Van Kerrebroeck V

Abstract excerpt

Characterizing the capabilities, key dependencies, and response to perturbations of genome-scale metabolic networks is a basic problem with important applications. A key question concerns the identification of the potentially most harmful reaction knockouts. The integration of combinatorial methods with sampling techniques to explore the space of viable flux states may provide crucial insights on this issue. We...

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Identifiers

PMID: 20706609
DOI: 10.1155/2010/415148
PMCID: PMC2914339

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