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Article

Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative.

Nature communications - 3 Aug 2018

Dai Zongjie, Huang Mingtao, Chen Yun, Siewers Verena, Nielsen Jens

Abstract excerpt

Saccharomyces cerevisiae is a Crabtree-positive eukaryal model organism. It is believed that the Crabtree effect has evolved as a competition mechanism by allowing for rapid growth and production of ethanol at aerobic glucose excess conditions. This inherent property of yeast metabolism and the multiple mechanisms underlying it require a global rewiring of the entire metabolic network to abolish the Crabtree...

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Identifiers

PMID: 30076310
DOI: 10.1038/s41467-018-05409-9
PMCID: PMC6076296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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