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Article

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.

Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2008

Haanstra Jurgen R, van Tuijl Arjen, Kessler Peter, Reijnders Willem, Michels Paul A M, Westerhoff Hans V, Parsons Marilyn, Bakker Barbara M

Abstract excerpt

ATP generation by both glycolysis and glycerol catabolism is autocatalytic, because the first kinases of these pathways are fuelled by ATP produced downstream. Previous modeling studies predicted that either feedback inhibition or compartmentation of glycolysis can protect cells from accumulation of intermediates. The deadly parasite Trypanosoma brucei lacks feedback regulation of early steps in glycolysis yet...

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Identifiers

PMID: 19008351
DOI: 10.1073/pnas.0806664105
PMCID: PMC2584722

Genes

PEX14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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