Article
Metabolic phenotypes of Saccharomyces cerevisiae mutants with altered trehalose 6-phosphate dynamics.
The Biochemical journal - 1 Sept 2013
Walther Thomas, Mtimet Narjes, Alkim Ceren, Vax Amélie, Loret Marie-Odile, Ullah Azmat, Gancedo Carlos, Smits Gertien J, François Jean Marie
Abstract excerpt
In Saccharomyces cerevisiae, synthesis of T6P (trehalose 6-phosphate) is essential for growth on most fermentable carbon sources. In the present study, the metabolic response to glucose was analysed in mutants with different capacities to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, TPS1, which had no measurable T6P, exhibited impaired ethanol production, showed diminished...
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