Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.

doi:10.1038/nm.3442

Article

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.

Nature medicine - 1 Mar 2014

Afshar-Sterle Shoukat, Zotos Dimitra, Bernard Nicholas J, Scherger Anna K, Rödling Lisa, Alsop Amber E, Walker Jennifer, Masson Frederick, Belz Gabrielle T, Corcoran Lynn M, O'Reilly Lorraine A, Strasser Andreas, Smyth Mark J, Johnstone Ricky, Tarlinton David M, Nutt Stephen L, Kallies Axel

Abstract excerpt

Loss of function of the tumor suppressor gene PRDM1 (also known as BLIMP1) or deregulated expression of the oncogene BCL6 occurs in a large proportion of diffuse large B cell lymphoma (DLBCL) cases. However, targeted mutation of either gene in mice leads to only slow and infrequent development of malignant lymphoma, and despite frequent mutation of BCL6 in activated B cells of healthy individuals, lymphoma...

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Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.

Abstract excerpt

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