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Article

A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.

Cancer research - 1 Jun 2007

Villa-Morales María, Santos Javier, Pérez-Gómez Eduardo, Quintanilla Miguel, Fernández-Piqueras José

Abstract excerpt

The Fas/FasL system mediates induced apoptosis of immature thymocytes and peripheral T lymphocytes, but little is known about its implication in genetic susceptibility to T-cell malignancies. In this article, we report that the expression of FasL increases early in all mice after gamma-radiation treatments, maintaining such high levels for a long time in mice that resisted tumor induction. However, its expression...

Topics

Animals
Base Sequence
Cloning, Molecular
DNA, Complementary
Fas Ligand Protein
Genetic Predisposition to Disease
Humans
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Promoter Regions, Genetic

Reverse Transcriptase Polymerase Chain Reaction

Transcription, Genetic

fas Receptor

Source

Identifiers

PMID: 17545588
DOI: 10.1158/0008-5472.CAN-06-4006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.PMID 17545588Read ↗

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