Article
A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.
Cancer research - 1 Jun 2007
Villa-Morales María, Santos Javier, Pérez-Gómez Eduardo, Quintanilla Miguel, Fernández-Piqueras José
Abstract excerpt
The Fas/FasL system mediates induced apoptosis of immature thymocytes and peripheral T lymphocytes, but little is known about its implication in genetic susceptibility to T-cell malignancies. In this article, we report that the expression of FasL increases early in all mice after gamma-radiation treatments, maintaining such high levels for a long time in mice that resisted tumor induction. However, its expression...
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