Article
Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma.
Blood - 8 Sept 2022
Pindzola Grace M, Razzaghi Raud, Tavory Rachel N, Nguyen Hang T, Morris Vivian M, Li Moyi, Agarwal Shreya, Huang Bonnie, Okada Takaharu, Reinhardt Hans C, Knittel Gero, Kashkar Hamid, Young Ryan M, Pittaluga Stefania, Muppidi Jagan R
Abstract excerpt
Unique molecular vulnerabilities have been identified in the aggressive MCD/C5 genetic subclass of diffuse large B-cell lymphoma (DLBCL). However, the premalignant cell-of-origin exhibiting MCD-like dependencies remains elusive. In this study, we examined animals carrying up to 4 hallmark genetic lesions found in MCD consisting of gain-of-function mutations in Myd88 and Cd79b, loss of Prdm1, and overexpression of...
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