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Article

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.

The Journal of cell biology - 25 Feb 2008

Vaccari Thomas, Lu Han, Kanwar Ritu, Fortini Mark E, Bilder David

Abstract excerpt

Signaling through the transmembrane receptor Notch is widely used throughout animal development and is a major regulator of cell proliferation and differentiation. During canonical Notch signaling, internalization and recycling of Notch ligands controls signaling activity, but the involvement of endocytosis in activation of Notch itself is not well understood. To address this question, we systematically assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18299346
DOI: 10.1083/jcb.200708127
PMCID: PMC2265571

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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.PMID 18299346Read ↗

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