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Article

Leukemogenesis: small differences in Myb have large effects.

Current biology : CB - 7 May 1998

Graf T

Abstract excerpt

The avian retroviruses E26 and AMV carry mutated versions of the gene encoding the cellular transcription factor c-Myb. Surprisingly, these two mutant forms of Myb differ in the subsets of myeloid cells that they transform, the target genes that they activate, and the way in which they are regula...

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Source

Identifiers

PMID: 9601636
DOI: 10.1016/s0960-9822(98)70220-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9601636-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Leukemogenesis: small differences in Myb have large effects.PMID 9601636Read ↗

MYB oncoproteins: emerging players and potential therapeutic targets in human cancerSemantic proximity Read ↗

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Semantic proximity Read ↗

Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Semantic proximity Read ↗

Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML.Semantic proximity Read ↗

Myb drives B-cell neoplasms and myeloid malignancies in vivoSemantic proximity Read ↗

BM2L is a spontaneous leukemogenic variant of a non-leukemogenic v-myb-transformed myeloid cell line.Semantic proximity Read ↗

Myb-induced transformation.Semantic proximity Read ↗

Alternative RNA Splicing Produces Multiple Forms of c-Myb with Unique Transcriptional ActivitiesSemantic proximity Read ↗

MYB function in normal and cancer cells.Semantic proximity Read ↗

Mechanisms for the transformation of myeloid and erythroid cells by the nuclear oncogene V-myb.Semantic proximity Read ↗

Positive and negative determinants of target gene specificity in myb transcription factors.Semantic proximity Read ↗

Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb.Semantic proximity Read ↗

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