Article
Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML.
Cell death & disease - 23 Nov 2023
Negri A, Ward C, Bucci A, D'Angelo G, Cauchy P, Radesco A, Ventura A B, Walton D S, Clarke M, Mandriani B, Pappagallo S A, Mondelli P, Liao K, Gargano G, Zaccaria G M, Viggiano L, Lasorsa F M, Ahmed A, Di Molfetta D, Fiermonte G, Cives M, Guarini A, Vegliante M C, Ciavarella S, Frampton J, Volpe G
Abstract excerpt
The transcription factor MYB plays a pivotal role in haematopoietic homoeostasis and its aberrant expression is involved in the genesis and maintenance of acute myeloid leukaemia (AML). We have previously demonstrated that not all AML subtypes display the same dependency on MYB expression and that such variability is dictated by the nature of the driver mutation. However, whether this difference in MYB dependency...
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