Article
Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.
Journal of virology - 1 Apr 1995
Dini P W, Eltman J T, Lipsick J S
Abstract excerpt
The v-Myb protein encoded by avian myeloblastosis virus causes oncogenic transformation of monoblastic cells committed to the monocyte/macrophage lineage. v-Myb is a doubly truncated form of its normal cellular counterpart, c-Myb. In addition to its N- and C-terminal deletions, v-Myb contains a number of amino acid substitutions relative to c-Myb. We have previously shown that neither overexpression of c-Myb nor...
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