Article
Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.
Journal of virology - 1 Apr 1995
Dini P W, Eltman J T, Lipsick J S
Abstract excerpt
The v-Myb protein encoded by avian myeloblastosis virus causes oncogenic transformation of monoblastic cells committed to the monocyte/macrophage lineage. v-Myb is a doubly truncated form of its normal cellular counterpart, c-Myb. In addition to its N- and C-terminal deletions, v-Myb contains a n...
Topics
- Acetyltransferases
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- Cell Transformation, Viral
- DNA, Viral
- DNA-Binding Proteins
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Oncogene Proteins v-myb
- Protein Binding
- Proteins
- Retroviridae Proteins, Oncogenic
- Transcriptional Activation