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Article

Positive and negative determinants of target gene specificity in myb transcription factors.

The Journal of biological chemistry - 9 Jul 2004

Lei Wanli, Rushton John J, Davis Lisa M, Liu Fan, Ness Scott A

Abstract excerpt

The A-Myb and c-Myb transcription factors share a highly conserved DNA-binding domain and activate the same promoters in reporter gene assays. However, the two proteins have distinct biological activities, and expressing them individually in human cells leads to the activation of distinct sets of endogenous genes, suggesting that each protein has a unique transcriptional specificity. Here, the structural and...

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Source

Identifiers

PMID: 15105423
DOI: 10.1074/jbc.M403133200

Genes

DHRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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