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Article

Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.

Cell - 25 Aug 1995

Du Z, Lang S M, Sasseville V G, Lackner A A, Ilyinskii P O, Daniel M D, Jung J U, Desrosiers R C

Abstract excerpt

Residues 17 and 18 in nef of SIVmac239 were changed from RQ to YE to create a translated sequence of SRPSGDLYERLLRARGETYGRLLGEVEDGYSQSP from residues 10-43. The YXXL motifs in this context match very well with consensus sequences for SH2 binding domains and are similar to ones present in nef of the acutely lethal pathogen SIVpbj14. The YE variant of SIVmac239, unlike SIVmac239 but like SIVpbj14, replicated well...

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PMID: 7664345
DOI: 10.1016/0092-8674(95)90038-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.PMID 7664345Read ↗

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A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral ReplicationSemantic proximity Read ↗

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Nef genes of SIV.Semantic proximity Read ↗

Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, NefSemantic proximity Read ↗

Prolonged infection in rhesus macaques with simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variants.Semantic proximity Read ↗

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