Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.

doi:10.1016/0092-8674(95)90038-1

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Article

Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.

Cell - 25 Aug 1995

Du Z, Lang S M, Sasseville V G, Lackner A A, Ilyinskii P O, Daniel M D, Jung J U, Desrosiers R C

Abstract excerpt

Residues 17 and 18 in nef of SIVmac239 were changed from RQ to YE to create a translated sequence of SRPSGDLYERLLRARGETYGRLLGEVEDGYSQSP from residues 10-43. The YXXL motifs in this context match very well with consensus sequences for SH2 binding domains and are similar to ones present in nef of t...

Topics

3T3 Cells
Alleles
Amino Acid Sequence
Animals
Base Sequence
DNA Primers
DNA, Viral
Gene Products, env
Gene Products, nef
Genes, nef
Lymphocyte Activation
Macaca mulatta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Phagocytes

Phenotype

Phosphorylation

Retroviridae Proteins, Oncogenic

Source

Open in PubMed

Identifiers

PMID: 7664345
DOI: 10.1016/0092-8674(95)90038-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7664345-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.PMID 7664345Read ↗

The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages.Semantic proximity Read ↗

Loss of the SIVsmmPBj14 phenotype and nef genotype during long-term survival of macaques infected by mucosal routes.Semantic proximity Read ↗

Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239.Semantic proximity Read ↗

Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.Semantic proximity Read ↗

A Truncated Form of Nef Selected during Pathogenic Reversion of Simian Immunodeficiency Virus SIVmac239Δnef Increases Viral ReplicationSemantic proximity Read ↗

Determinants of Increased Replicative Capacity of Serially Passaged Simian Immunodeficiency Virus with nef Deleted in Rhesus MonkeysSemantic proximity Read ↗

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.Semantic proximity Read ↗

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Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.Semantic proximity Read ↗

Nef genes of SIV.Semantic proximity Read ↗

Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, NefSemantic proximity Read ↗

Prolonged infection in rhesus macaques with simian immunodeficiency virus (SIVmac239) results in animal-specific and rarely tissue-specific selection of nef variants.Semantic proximity Read ↗

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