Progression to AIDS in macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population.

doi:10.1006/viro.1995.1113

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Article

Progression to AIDS in macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population.

Virology - 10 Mar 1995

Rudensey L M, Kimata J T, Benveniste R E, Overbaugh J

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) typically evolves from a macrophage-tropic, noncytopathic virus at early asymptomatic stages of infection to a T-cell-tropic, cytopathic, and syncytia-inducing virus population as humans progress to AIDS. This suggests that changes in virus phenotype may influence disease. Because simian immunodeficiency virus (SIV) infection in macaques is a common model system for...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Animals
Cell Line
Cells, Cultured
Cytopathogenic Effect, Viral
Genes, env
Genetic Variation
HIV-1
Humans
Macaca nemestrina

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Molecular Sequence Data

Phenotype

Sequence Homology, Amino Acid

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 7886956
DOI: 10.1006/viro.1995.1113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7886956-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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