Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.

Journal of virology - 1 Oct 2015

Rainho Jennifer N, Martins Mauricio A, Cunyat Francesc, Watkins Ian T, Watkins David I, Stevenson Mario

Abstract excerpt

UNLABELLED: Simian immunodeficiency virus (SIV)-specific CD8(+) T cells kill SIV-infected CD4(+) T cells in an major histocompatibility complex class I (MHC-I)-dependent manner. However, they are reportedly less efficient at killing SIV-infected macrophages. Since the viral accessory protein Nef has been shown to downregulate MHC-I molecules and enhance cytotoxic T lymphocyte (CTL) evasion in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Immune Evasion

Share to Macaca mulatta

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26269172
DOI: 10.1128/JVI.01699-15
PMCID: PMC4580207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.PMID 26269172Read ↗

Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus InfectionsSemantic proximity Read ↗

Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency VirusSemantic proximity Read ↗

Macrophages and their relevance in Human Immunodeficiency Virus Type I infectionSemantic proximity Read ↗

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo.Semantic proximity Read ↗

The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs.Semantic proximity Read ↗

CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4 + T-Cell Depletion in Human Lymphoid Tissue Ex VivoSemantic proximity Read ↗

Macrophages and Cell-Cell Spread of HIV-1Semantic proximity Read ↗

Macrophages and HIV-1Semantic proximity Read ↗

HIV and SIV infection: the role of cellular restriction and immune responses in viral replication and pathogenesis.Semantic proximity Read ↗

Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T LymphocytesSemantic proximity Read ↗

The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.Semantic proximity Read ↗

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 IsolateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.