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Article

Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.

Retrovirology - 2 Mar 2011

Tschulena Ulrich, Sanzenbacher Ralf, Mühlebach Michael D, Berger André, Münch Jan, Schindler Michael, Kirchhoff Frank, Plesker Roland, Coulibaly Cheick, Panitz Sylvia, Prüfer Steffen, Muckenfuss Heide, Hamdorf Matthias, Schweizer Matthias, Cichutek Klaus, Flory Egbert

Abstract excerpt

BACKGROUND: The non-pathogenic course of SIV infection in its natural host is characterized by robust viral replication in the absence of chronic immune activation and T cell proliferation. In contrast, acutely lethal enteropathic SIVsmm strain PBj induces a strong immune activation and causes a severe acute and lethal disease in pig-tailed macaques after cross-species transmission. One important pathogenicity...

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Identifiers

PMID: 21366921
DOI: 10.1186/1742-4690-8-14
PMCID: PMC3060844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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