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Article

Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.

Journal of molecular biology - 12 Apr 2013

Campanello Gregory C, Ma Zhen, Grossoehme Nicholas E, Guerra Alfredo J, Ward Brian P, Dimarchi Richard D, Ye Yuzhen, Dann Charles E, Giedroc David P

Abstract excerpt

The molecular basis of allosteric regulation remains a subject of intense interest. Staphylococcus aureus CzrA is a member of the ubiquitous arsenic repressor (ArsR) family of bacterial homodimeric metal-sensing proteins and has emerged as a model system for understanding allosteric regulation of operator DNA binding by transition metal ions. Using unnatural amino acid substitution and a standard linkage...

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Identifiers

PMID: 23353829
DOI: 10.1016/j.jmb.2013.01.018
PMCID: PMC3602352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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