Article
Novel mutations in the polyadenine tract of the transforming growth factor beta type II receptor gene are found in a subpopulation of human pancreatic adenocarcinomas.
Genes, chromosomes & cancer - 1 Jun 1998
Venkatasubbarao K, Ahmed M M, Swiderski C, Harp C, Lee E Y, McGrath P, Mohiuddin M, Strodel W, Freeman J W
Abstract excerpt
In this study, we determined the incidence of microsatellite instability (MIN) in pancreatic adenocarcinoma and determined whether MIN might target, for mutations, the simple nucleotide repeats of the transforming growth factor beta type II receptor (TGFBR2) gene. Forty-eight surgically resected...
Topics
- Adenocarcinoma
- Colonic Neoplasms
- Humans
- Incidence
- Microsatellite Repeats
- Mutation
- Pancreatic Neoplasms
- Poly A
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta