Article
Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressure.
BMC genetics - 31 Dec 2003
Kopciuk Karen A, Briollais Laurent, Demenais Florence, Bull Shelley B
Abstract excerpt
BACKGROUND: Genetic studies of complex disorders such as hypertension often utilize families selected for this outcome, usually with information obtained at a single time point. Since age-at-onset for diagnosed hypertension can vary substantially between individuals, a phenotype based on long-ter...
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