Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information.

PloS one - 31 Aug 2009

Pitkäniemi Janne, Varvio Sirkka-Liisa, Corander Jukka, Lehti Nella, Partanen Jukka, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Thomas Andrew, Arjas Elja

Abstract excerpt

BACKGROUND: In genetic studies of rare complex diseases it is common to ascertain familial data from population based registries through all incident cases diagnosed during a pre-defined enrollment period. Such an ascertainment procedure is typically taken into account in the statistical analysis of the familial data by constructing either a retrospective or prospective likelihood expression, which conditions on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Demography

Share to Finland

Share to Genetic Predisposition to Disease

Share to Likelihood Functions

Share to Registries

Source

Open in PubMed Open full text

Identifiers

PMID: 19718441
DOI: 10.1371/journal.pone.0006836
PMCID: PMC2730012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information.PMID 19718441Read ↗

Genetic random effects model for family data with long-term survivors: analysis of diabetic nephropathy in type 1 diabetes.Semantic proximity Read ↗

PEL: an unbiased method for estimating age-dependent genetic disease risk from pedigree data unselected for family history.Semantic proximity Read ↗

Estimation of transmission probabilities in families ascertained through a proband with variable age-at-onset disease: application to the HLA A, B and DR loci in Finnish families with type 1 diabetes. The DiMe Study Group.Semantic proximity Read ↗

Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach.Semantic proximity Read ↗

A general test of association for complex diseases with variable age of onset.Semantic proximity Read ↗

Multifactorial disease risk calculator: Risk prediction for multifactorial disease pedigrees.Semantic proximity Read ↗

Class I and II HLA genes are associated with susceptibility and age at onset in Finnish families with type 1 diabetes.Semantic proximity Read ↗

Computing Individual Risks Based on Family History in Genetic Disease in the Presence of Competing Risks.Semantic proximity Read ↗

Case-sibling gene-association studies for diseases with variable age at onset.Semantic proximity Read ↗

Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.Semantic proximity Read ↗

Empirical Bayes methods for testing associations with large numbers of candidate genes in the presence of environmental risk factors, with applications to HLA associations in IDDM.Semantic proximity Read ↗

Estimating haplotype relative risks in complex disease from unphased SNPs data in families using a likelihood adjusted for ascertainment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.