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Article

Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.

The Journal of infectious diseases - 1 Apr 1994

Shafer R W, Kozal M J, Winters M A, Iversen A K, Katzenstein D A, Ragni M V, Meyer W A, Gupta P, Rasheed S, Coombs R

Abstract excerpt

Drug resistance conferred by specific human immunodeficiency virus type 1 (HIV-1) pol gene mutations has been associated with clinical progression in HIV-infected patients receiving anti-retroviral therapy. This study examined drug susceptibilities and pol mutations of HIV-1 strains from patients treated for 1 year with zidovudine, didanosine (ddI), or zidovudine and ddI. Ten (42%) of 24 patients receiving...

Topics

Amino Acids
Base Sequence
Cells, Cultured
Codon
DNA Primers
DNA, Viral
Didanosine
Drug Resistance, Microbial
Drug Therapy, Combination
Genes, pol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Seropositivity

HIV-1

Humans

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Proviruses

RNA, Viral

Source

Identifiers

PMID: 8133086
DOI: 10.1093/infdis/169.4.722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8133086-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.PMID 8133086Read ↗

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