Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy.

doi:10.1038/361650a0

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Article

Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy.

Nature - 18 Feb 1993

Chow Y K, Hirsch M S, Merrill D P, Bechtel L J, Eron J J, Kaplan J C, D'Aquila R T

Abstract excerpt

Wild-type reverse transcriptase has evolved for the survival of human immunodeficiency virus type 1 (HIV-1) by natural selection. In contrast, therapy relying on inhibitors of reverse transcriptase by nucleosides like zidovudine (AZT) or dideoxyinosine (ddI), and by non-nucleosides like pyridinones or nevirapine, may exert different selection pressures on this enzyme. Therefore the acquisition of resistance to...

Topics

Acquired Immunodeficiency Syndrome
Biological Evolution
DNA, Viral
Didanosine
Drug Resistance, Microbial
Drug Therapy, Combination
HIV Reverse Transcriptase
HIV-1
Humans
Mutation
Nevirapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Pyridines

Pyridones

RNA-Directed DNA Polymerase

Reverse Transcriptase Inhibitors

Selection, Genetic

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 7679778
DOI: 10.1038/361650a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7679778-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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