Article
Thymic anti-tumor effectors in mice cured of lymphoma by cyclophosphamide plus TNF-alpha therapy: phenotypic and functional characterization up to 20 months after initial tumor inoculation.
International journal of cancer - 18 May 1998
Ehrke M J, Verstovsek S, Pocchiari S K, Krawczyk C M, Ujházy P, Zaleskis G, Maccubbin D L, Meer J M, Mihich E
Abstract excerpt
As reported previously, cyclophosphamide plus tumor necrosis factor-alpha treatment of C57BL/6 mice bearing advanced EL4 lymphoma induced approx. 60% long-term (i.e., >60 days) survivors. These mice developed protective immunity, as evidenced by 1) rejection (100% survival) of EL4 tumor re-implan...
Topics
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cyclophosphamide
- Female
- Leukemia, Myeloid
- Mice
- Mice, Inbred C57BL
- Neoplasm Transplantation
- Phenotype
- Thymus Gland
- Time Factors