Article
Adoptively transferred ex vivo activated memory T cells with cyclophosphamide: effective tumor-specific chemoimmunotherapy of advanced metastatic murine melanoma and carcinoma.
Clinical immunology and immunopathology - 1 Oct 1994
Gold J E, Zachary D T, Osband M E
Abstract excerpt
Autolymphocyte therapy (ALT) is adoptive cellular therapy of neoplastic disease based upon ex vivo activation of autologous peripheral blood mononuclear cells by either the supernatant derived from a previously prepared one-way mixed lymphocyte culture (MLC) or using low doses of the mitogenic mo...
Topics
- Animals
- Antibodies, Neoplasm
- Antibody Specificity
- Antilymphocyte Serum
- Carcinoma
- Combined Modality Therapy
- Cyclophosphamide
- Immunity
- Immunologic Memory
- Immunotherapy, Adoptive
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Neoplasms, Experimental
- Phenotype
- Spleen
- T-Lymphocytes