Article
The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.
Blood - 27 Oct 2011
Schuster Christian, Berger Angelika, Hoelzl Maria A, Putz Eva M, Frenzel Anna, Simma Olivia, Moritz Nadine, Hoelbl Andrea, Kovacic Boris, Freissmuth Michael, Müller Mathias, Villunger Andreas, Müllauer Leonard, Schmatz Ana-Iris, Streubel Berthold, Porpaczy Edit, Jäger Ulrich, Stoiber Dagmar, Sexl Veronika
Abstract excerpt
In Eμ-myc transgenic animals lymphoma formation requires additional genetic alterations, which frequently comprise loss of p53 or overexpression of BCL-2. We describe that the nature of the "second hit" affects the ability of the immune system to contain lymphoma development. Tumors with disrupted p53 signaling killed the host more rapidly than BCL-2 overexpressing ones. Relaxing immunologic control, using...
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