Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymic lymphomas mediate non-MHC-restricted, TNF-dependent lysis of the murine sarcoma WEHI-164.

Cellular immunology - 1 Aug 1991

Lattime E C, Stutman O

Abstract excerpt

Tumor necrosis factor (TNF), lyses a range of sensitive tumor targets and has been shown to be the mediator of natural cytotoxic (NC) activity first described in our laboratory. In this report, we identify two thymic lymphoma cell lines which lyse the prototype NC target WEHI-164 and share characteristics of NC. R1.1E and L5178-27av lyse the WEHI-164 sarcoma in 18-hr 51Cr release assays via a TNF-dependent,...

Topics

Animals
Antibodies, Monoclonal
Cytotoxicity, Immunologic
Female
Gangliosides
Lymphoma
Mice
Mice, Inbred BALB C
Phenotype
Sarcoma, Experimental
Spleen
Thymus Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 2060025
DOI: 10.1016/0008-8749(91)90382-l

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2060025-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymic lymphomas mediate non-MHC-restricted, TNF-dependent lysis of the murine sarcoma WEHI-164.PMID 2060025Read ↗

Establishment of an immortalized T-cell line from lung cancer tissue: phenotypic and functional analyses.Semantic proximity Read ↗

Generation of syngeneic anti-tumour double negative cells (CD4- CD8-), with cytotoxic activity against clones of different MHC class I expression.Semantic proximity Read ↗

Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemiaSemantic proximity Read ↗

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact.Semantic proximity Read ↗

An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease.Semantic proximity Read ↗

Natural cell-mediated cytotoxicity (NCMC) against NK-sensitive tumours in vitro by murine spleen Ly-6C+ natural T cells.Semantic proximity Read ↗

TCR-independent killing of B cell malignancies by anti-third-party CTLs: the critical role of MHC-CD8 engagement.Semantic proximity Read ↗

A single amino acid variation within an immunodominant AKR/Gross MuLV cytotoxic T-lymphocyte epitope leads to a loss in immunogenicity.Semantic proximity Read ↗

Natural Killer Cell-Mediated Killing of Freshly Isolated Neuroblastoma CellsSemantic proximity Read ↗

Assessment of lymphocyte-mediated cytotoxicity using flow cytometry.Semantic proximity Read ↗

Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanisms.Semantic proximity Read ↗

In vitro cytolytic activity of lymphocytes from tumor-draining lymph nodes is associated with increased numbers of CD8+ cells and increased cytokine production.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.