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Article

TCR-independent killing of B cell malignancies by anti-third-party CTLs: the critical role of MHC-CD8 engagement.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2011

Lask Assaf, Goichberg Polina, Cohen Adva, Goren-Arbel Rinat, Milstein Oren, Aviner Shraga, Feine Ilan, Ophir Eran, Reich-Zeliger Shlomit, Hagin David, Klein Tirza, Nagler Arnon, Berrebi Alain, Reisner Yair

Abstract excerpt

We previously demonstrated that anti-third-party CTLs (stimulated under IL-2 deprivation against cells with an MHC class I [MHC-I] background different from that of the host and the donor) are depleted of graft-versus-host reactivity and can eradicate B cell chronic lymphocytic leukemia cells in vitro or in an HU/SCID mouse model. We demonstrated in the current study that human allogeneic or autologous...

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Identifiers

PMID: 21753148
DOI: 10.4049/jimmunol.1100095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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