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Article

Molecular characterization of Patched-associated rhabdomyosarcoma.

The Journal of pathology - 1 Jul 2003

Kappler Roland, Calzada-Wack Julia, Schnitzbauer Udo, Koleva Milena, Herwig Astrid, Piontek Guido, Graedler Florian, Adamski Jerzy, Heinzmann Ulrich, Schlegel Jürgen, Hemmerlein Bernhard, Quintanilla-Martinez Leticia, Hahn Heidi

Abstract excerpt

Mutations in the human homologue of Drosophila Patched1 (PTCH1) have been found in several common tumours including basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma (RMS). Medulloblastoma and RMS are also present in the murine model for Ptch1 deficiency. Tumours in heterozygous Ptch1(neo67/+) mice consistently exhibit elevated transcript levels of the proto-oncogene Gli1, of Ptch1 itself, and of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12845631
DOI: 10.1002/path.1361

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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