Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Basal cell carcinomas in mice overexpressing sonic hedgehog.

Science (New York, N.Y.) - 2 May 1997

Oro A E, Higgins K M, Hu Z, Bonifas J M, Epstein E H, Scott M P

Abstract excerpt

Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Mice, Transgenic
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Intracellular Signaling Peptides and Proteins

Share to Membrane Proteins

Share to Neoplasm Transplantation

Source

Identifiers

PMID: 9115210
DOI: 10.1126/science.276.5313.817

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9115210-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Basal cell carcinomas in mice overexpressing sonic hedgehog.PMID 9115210Read ↗

Correlations between the Sonic Hedgehog pathway and basal cell carcinoma.Semantic proximity Read ↗

Sonic Hedgehog Signaling in Basal Cell Nevus SyndromeSemantic proximity Read ↗

The patched signaling pathway in tumorigenesis and development: lessons from animal models.Semantic proximity Read ↗

Hedgehog signalling in skin development and cancerSemantic proximity Read ↗

The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics.Semantic proximity Read ↗

Altered neural cell fates and medulloblastoma in mouse patched mutants.Semantic proximity Read ↗

Activating Smoothened mutations in sporadic basal-cell carcinoma.Semantic proximity Read ↗

The hedgehog pathway and basal cell carcinomas.Semantic proximity Read ↗

The role of hedgehog signalling in tumorigenesis.Semantic proximity Read ↗

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic HedgehogSemantic proximity Read ↗

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.Semantic proximity Read ↗

Patched Knockout Mouse Models of Basal Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.