Article
Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers.
Diseases of the colon and rectum - 1 Aug 2003
Jeong Seung-Yong, Shin Ki-Hyuk, Shin Joo-Ho, Ku Ja-Lok, Shin Young-Kyoung, Park So-Yeon, Kim Woo-Ho, Park Jae-Gahb
Abstract excerpt
PURPOSE: This study was designed to investigate the frequency of mutations in DNA mismatch repair genes in sporadic colorectal cancers. METHODS: Genomic DNAs procured from paraffin blocks of the pathologic specimens from 230 consecutive patients with colorectal cancer were examined for their microsatellite instability status using a mononucleotide microsatellite marker, BAT-26, and also evaluated expressions of...
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