Article
Clonal expansion of T-cell receptor beta gene segment in the retrocochlear lesions of EAE mice.
ORL; journal for oto-rhino-laryngology and its related specialties - 1 Jan 2000
Cheng K C, Lee K M, Yoo T J
Abstract excerpt
It has been reported that the T cell receptor V beta 8.2 (TcrbV8.2) gene segment is predominantly expressed in encephalomyelitic T cells responding to myelin basic protein (MBP) in experimental allergic encephalomyelitis (EAE) mice. We have demonstrated retrocochlear hearing loss in EAE mice in previous studies. Administration of a monoclonal antibody specific to the T cell receptor V beta 8 (TcrbV8) subfamily...
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