Interallelic V(D)J trans-rearrangement within the beta T cell receptor gene is infrequent and occurs preferentially during attempted D beta to J beta joining.

Abstract excerpt

Previous work has demonstrated that intergenic V(D)J rearrangement, a process referred to as trans-rearrangement, occurs at an unexpectedly high frequency. These rearrangements generate novel V(D)J combinations which could conceivably have some role in the normal immune system, and since they pro...

Topics

• Alleles
• Animals
• Base Sequence
• Blotting, Southern
• Chromosome Deletion
• DNA
• Gene Frequency
• Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
• Immunoglobulin Joining Region
• Immunoglobulin Variable Region
• Mice
• Mice, Inbred BALB C
• Mice, Inbred Strains
• Molecular Sequence Data