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Article

Interallelic V(D)J trans-rearrangement within the beta T cell receptor gene is infrequent and occurs preferentially during attempted D beta to J beta joining.

The Journal of experimental medicine - 1 Jun 1992

Aster J C, Sklar J

Abstract excerpt

Previous work has demonstrated that intergenic V(D)J rearrangement, a process referred to as trans-rearrangement, occurs at an unexpectedly high frequency. These rearrangements generate novel V(D)J combinations which could conceivably have some role in the normal immune system, and since they probably arise through chromosomal rearrangements akin to those associated with lymphoid neoplasia, they may also serve as...

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Identifiers

PMID: 1316933
DOI: 10.1084/jem.175.6.1773
PMCID: PMC2119263

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