Article
Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (Vbeta8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens.
International immunology - 1 May 2004
Kreiss Matthias, Asmuss Anne, Krejci Kathrin, Lindemann Dirk, Miyoshi-Akiyama Tohru, Uchiyama Takehiko, Rink Lothar, Broeren Chris P M, Herrmann Thomas
Abstract excerpt
In experimental autoimmune encephalomyelitis (EAE) of LEW rats, BV8S2(+) (V(beta)8.2) T cells dominate the RT1B(l)-restricted response to guinea pig myelin basic protein (gpMBP), and respond to the superantigens (SAg) Staphylococcus enterotoxin C1 (SEC1), Mycoplasma arthritidis SAg (MAS) and Yersinia pseudotuberculosis mitogen (YPM). T cells expressing the closely related BV8S4 differ from BV8S2 T cells in their...
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