Myelin basic protein-specific and TCR V beta 8.2-specific T-cell lines from TCR V beta 8.2 transgenic mice utilize the same V alpha and V beta genes: specificity associated with the V alpha CDR3-J alpha region.

Abstract excerpt

Our analysis of TCR V gene usage in mice transgenic for the V beta 8.2 gene has demonstrated that T cells isolated from the spinal cord of these transgenic mice during active experimental autoimmune encephalomyelitis were significantly biased for V alpha 2 expression. This V alpha 2 bias was note...

Topics

• Animals
• Antibody Specificity
• Base Sequence
• Cell Line
• Mice
• Mice, Transgenic
• Molecular Sequence Data
• Myelin Basic Protein
• Phenotype
• Receptors, Antigen, T-Cell, alpha-beta
• T-Lymphocytes