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Article

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.

Developmental biology - 15 Apr 1998

Thomas T, Yamagishi H, Overbeek P A, Olson E N, Srivastava D

Abstract excerpt

dHAND and eHAND are basic helix-loop-helix transcription factors that play critical roles in cardiac development. The HAND genes have a complementary left-right cardiac asymmetry of expression with dHAND predominantly on the right side and eHAND on the left side of the looped heart tube. Here we...

Topics

Animals
Basic Helix-Loop-Helix Transcription Factors
Body Patterning
Crosses, Genetic
DNA-Binding Proteins
Gene Expression Regulation, Developmental
Genotype
Heart Ventricles
Helix-Loop-Helix Motifs
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Morphogenesis

RNA, Messenger

Transcription Factors

Zebrafish Proteins

Source

Identifiers

PMID: 9576835
DOI: 10.1006/dbio.1998.8849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9576835-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.PMID 9576835Read ↗

HAND proteins: molecular mediators of cardiac development and congenital heart disease.Semantic proximity Read ↗

A GATA-dependent right ventricular enhancer controls <i>dHAND</i> transcription in the developing heartSemantic proximity Read ↗

Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.Semantic proximity Read ↗

In-Silico analysis of HAND subclass bHLH transcription factor in CardiogenesisSemantic proximity Read ↗

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.Semantic proximity Read ↗

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.Semantic proximity Read ↗

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heartSemantic proximity Read ↗

The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.Semantic proximity Read ↗

HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

Congenital heart disease and the specification of left-right asymmetrySemantic proximity Read ↗

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