Article
Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.
Genes & development - 1 Jun 1997
Biben C, Harvey R P
Abstract excerpt
One of the first morphological manifestations of left/right (L/R) asymmetry in mammalian embryos is a pronounced rightward looping of the linear heart tube. The direction of looping is thought to be controlled by signals from an embryonic L/R axial system. We report here that morphological L/R as...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- DNA-Binding Proteins
- Genotype
- Heart
- Helix-Loop-Helix Motifs
- Homeobox Protein Nkx-2.5
- Homeodomain Proteins
- In Situ Hybridization
- Mice
- Models, Genetic
- Morphogenesis
- Mutation
- Tissue Distribution
- Transcription Factors
- Xenopus Proteins