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Article

Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary.

World journal of gastroenterology - 7 Jan 2008

Nagahashi Masayuki, Ajioka Yoichi, Lang Istvan, Szentirmay Zoltan, Kasler Miklos, Nakadaira Hiroto, Yokoyama Naoyuki, Watanabe Gen, Nishikura Ken, Wakai Toshifumi, Shirai Yoshio, Hatakeyama Katsuyoshi, Yamamoto Masaharu

Abstract excerpt

AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary. METHODS: We examined 42 cases of gallbladder carcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent...

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Identifiers

PMID: 18176964
DOI: 10.3748/wjg.14.70
PMCID: PMC2673394

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Source receipt: pubmed, retrieved 7 Sept 2026.

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