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Article

TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma.

Annals of hepatology - 1 Jan 2000

Moreno Mauricio, Pimentel Fernando, Gazdar Adi F, Wistuba Ignacio I, Miquel Juan F

Abstract excerpt

BACKGROUND: Gallbladder carcinoma (GBC) is a frequent neoplasm in Hispanic and native American populations. GBC is preceded by gallstones, chronic cholecystitis and dysplastic changes of the gallbladder epithelium. The knowledge of the molecular events involved in its pathogenesis is scarce. AIMS: We investigated the role of TP53 inactivation in the sequential pathogenesis of GBC. METHODS: Invasive tumor-,...

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PMID: 16177659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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