Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile.

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Article

Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile.

Cancer research - 15 Jun 1995

Wistuba I I, Sugio K, Hung J, Kishimoto Y, Virmani A K, Roa I, Albores-Saavedra J, Gazdar A F

Abstract excerpt

Although gallbladder carcinoma is one of the most frequent neoplasms in Chile, there is limited information about the molecular changes involved in its pathogenesis. We investigated the incidence of ras gene mutations and loss of heterozygosity (LOH) at the following genes/loci: p53, DCC, rb, 5q 3p, 8p, and 9p. We precisely microdissected 194 relevant areas from paraffin-embedded microslides from 25 gallbladder...

Topics

Adenocarcinoma
Alleles
Base Sequence
Carcinoma, Small Cell
Chile
Chromosome Deletion
Chromosomes, Human
Epithelium
Gallbladder
Gallbladder Neoplasms
Genes, Retinoblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Genes, ras

Genetic Markers

Humans

Metaplasia

Mutation

Neoplasm Invasiveness

Source

Open in PubMed

Identifiers

PMID: 7780959

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7780959-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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