Article
11q13 allelotype analysis in 27 northern American MEN1 kindreds identifies two distinct founder chromosomes.
Molecular genetics and metabolism - 1 Feb 1998
Emmert-Buck M R, Debelenko L V, Agarwal S, Kester M B, Manickam P, Zhuang Z, Guru S C, Olufemi S E, Burns A L, Chandrasekharappa S C, Lubensky I A, Liotta L A, Skarulis M C, Spiegel A M, Marx S J, Collins F S
Abstract excerpt
We analyzed constitutional and tumor DNA from 27 MEN1 kindreds not known to be related to each other. Disease allele haplotypes were constructed for each pedigree based on shared alleles from two or more affected members and from determination of allelic loss patterns in their tumors. Analysis of...
Topics
- Alleles
- Chromosomes, Human, Pair 11
- Founder Effect
- Genetic Markers
- Haplotypes
- Humans
- Multiple Endocrine Neoplasia Type 1
- North America
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic