Article
A large multiple endocrine neoplasia type 1 family with clinical expression suggestive of anticipation.
The Journal of clinical endocrinology and metabolism - 1 Oct 1997
Giraud S, Choplin H, Teh B T, Lespinasse J, Jouvet A, Labat-Moleur F, Lenoir G, Hamon B, Hamon P, Calender A
Abstract excerpt
We describe a large multigenerational multiple endocrine neoplasia Type 1 (MEN1) family with clinical expression suggestive of anticipation. In the second and third generations, two deceased obligate gene carriers died at the ages of 85 and 76 without the history of MEN1, whereas two other living...
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- Cytogenetics
- Disease Progression
- Female
- Genetic Linkage
- Germ-Line Mutation
- Heterozygote
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Pedigree