Article
Genetic screening in hereditary multiple endocrine neoplasia type 1: absence of a founder effect among Japanese families.
Japanese journal of cancer research : Gann - 1 Sept 1996
Sakurai A, Katai M, Itakura Y, Nakajima K, Baba K, Hashizume K
Abstract excerpt
Ten Japanese families with hereditary multiple endocrine neoplasia type 1 (MEN1) were examined. Five DNA polymorphic markers on the long arm of chromosome 11 were analyzed for genetic screening of MEN1 in members of affected families, and disease carriers were identified before clinical manifesta...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Child
- DNA, Satellite
- Female
- Founder Effect
- Genetic Carrier Screening
- Genetic Testing
- Genotype
- Haplotypes
- Humans
- Japan
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Pedigree