Article
Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene.
Cancer research - 15 Mar 1997
Debelenko L V, Emmert-Buck M R, Manickam P, Kester M, Guru S C, DiFranco E M, Olufemi S E, Agarwal S, Lubensky I A, Zhuang Z, Burns A L, Spiegel A M, Liotta L A, Collins F S, Marx S J, Chandrasekharappa S C
Abstract excerpt
Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA, Neoplasm
- Female
- Genetic Markers
- Haplotypes
- Humans
- Male
- Multiple Endocrine Neoplasia Type 1
- Pedigree
- Polymorphism, Genetic
- Recombination, Genetic